The Detroit Lions are set to take on the Buffalo Bills in a thrilling regular season encounter on September 17, 2026, at Highmark Stadium in Orchard Park with kickoff slated for 8:15 pm.

The Lions, always a team to watch, will be looking to capitalize on this match to showcase their form and gain early momentum. Fans are eager to see how the team performs in this challenging matchup.

The Bills, hosting the game, represent a significant obstacle. The contest will be a key opportunity for the Lions to assess their strengths and weaknesses against a formidable opponent in a highly competitive setting.

Betting lines: Buffalo Bills -4.50, Detroit Lions 4.50. Total: 53.50. Moneyline: Buffalo Bills -218, Detroit Lions 180. (DraftKings)

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